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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF METHYLPREDNISOLONE IN BULK AND PHARMACEUTICAL FORMULATIONS
Vijaya Krishna C. Aradhya, Greeshma S. E.*, A. Satish Kumar Shetty, Anil kumar
ABSTRACT The aim of present work was to develop an simple, accurate and precise zero order derivative method and Area Under Curve (AUC) method for the estimation of methylprednisolone and validation according to ICH Q2(RI) guideline. The absorbance maxima was determined at 242nm using methanol as a solvent. The area selected for the estimation of methylprednisolone was between 237 to 247nm. The method represented the the correlation coefficient (R2=0.999) at concentration range 5-25mcg/ml. the method were validated for the parameters such as linearity, accuracy, precision, and limit of quantification, limit of detection as per ICH guidelines. The proposed method were thus found suitable for estimation of methylprednisolone in bulk and tablet formulation without any interference of the excipients. Keywords: Methylprednisolone, AUC, Validation. [Download Article] [Download Certifiate] |