Abstract

METFORMIN IN GESTATIONAL DIABETES MELLITUS-A REVIEW

Akhila T. S., Anand A. S., Liya Kuriakose, Shabina M. and Nithin Manohar R.*

ABSTRACT

Pregnancy is a potentially glucose intolerant condition and in all pregnancies insulin sensitivity decreases as pregnancy advances. This predisposes to development of gestational diabetes mellitus. Different treatment options are available for GDM. The first line treatment is medical nutrition therapy. When medical nutrition therapy fails to achieve adequate glucose control, pharmacotherapy is implemented which include oral hypoglycemic agents like metformin ,glyburide and insulin replacement therapy is also preferred. Metformin has begun to have a greater utilisation in GDM. Therefore it is important to understand the available data on metformin as treatment for GDM. This review highlights the benefits of metformin in GDM mothers and to assess its effectiveness against insulin and glyburide.

Keywords: Gestational diabetes mellitus, metformin, insulin, glyburide.