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OPTIMIZATION AND EVALUATION OF VALSARTAN FAST DISSOLVING TABLETS- EMPLOYING STARCH GLUTARATE - A NEW SUPERDISINTEGRANT
Dr. A. Bharathi* and D. Chandra Sekhar Naik
ABSTRACT
Valsartan is a Anti-hypertensive drugs which is insoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 23%). The dissolution rate of valsartan can be increased by formulating it into fast dissolving tablets, as these dosage forms disintegrate very rapidly into fine suspension of drug particles resulting in higher surface area of drug. Though, several disintegrants are available, there is continuous need to develop newer disintegrants to have more disintegration and dissolution efficiency. The present research work involves preparation, characterization and Keywords: Poorly Soluble, valsartan, Starch glutarate. [Download Article] [Download Certifiate] |