Abstract

COMPARATIVE ANTI-INFLAMMATORY ACTIVITY OF THE LEAVES OF TWO FLOWERING PLANTS (METHANOLIC EXTRACT)

Sangita Kumari*, Dr. Avijit Mazumder and Dr. S. Bhattacharya

ABSTRACT

Medicinal plants have a promising future because there are about half million plants around the world which are yet to be investigated for their medical properties, which could be decisive in the treatment of many diseases. The aim of the present work was to compare the antiinflammatory potentiality of methanolic extract Plumeria alba Linn. leaves (MELPA) and Tabernaemontana divaricata Linn. leaves (MELTD) of the family Apocynaceae. Extracts showed the dosedependent response for anti-inflammatory activity in a carrageenaninduced paw edema. The extract at a dose of 400 mg/kg (MELPA) was found to be most effective (% inhibition= 50.66%) and activity was comparable with standard anti-inflammatory drug indomethacin with percent inhibition of 57.82%. In the carrageenan induced inflammation, MELTD was found to be most effective with % inhibition of 33.8 and 44.8 respectively and the activity was comparable with standard anti-inflammatory drug indomethacin with percent inhibition of 60.5%. The methanolic extract of P. alba leaves was found to be more effective in carrageenan induced inflammation.

Keywords: Anti-inflammatory, Plumeria alba, Tabernaemontana divaricata, carrageenan, Apocynaceae.