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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

DEVELOPMENT OF A VALIDATED METHOD FOR ZOLEDRONIC ACID IN INJECTION FORM BY USING RP-HPLC

M. Chandana*, M. Prasadarao, N. Sai Prudhvi, CH. Siva Naga Lakshmi Deepthi, R. Venubabu, A. Sravani and B. Ravi Kumar

ABSTRACT

A new simple, accurate, precise and selective Reverse phase high performance liquid chromatographic (RP-HPLC) method was developed and for estimation of Zoledronic acid in pharmaceutical dosage form. An isocratic, reverse phase HPLC method was developed and validated using HypersilBds C18 (250x4.6mm,5μm)column, using the mobile phase of 2ml of trimethyl amine in 1000ml of water for injection and adjust the pH 3.2 with ortho-phosphoric acid and detection is carried out at a wave length of 215nm. The retention time for ZDA was found to be 3.413 mins thus the method is not time consuming and can be used in laboratories for the routine analysis of formulation. The method was validated in accordance with ICH parameters.

Keywords: Zoledronic acid, ZDA, RP-HPLC, validation.

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