Abstract

FORMULATION AND EVALUATION OF HERBAL FAST DISSOLVING BUCCAL FILM CONTAINING CURCUMIN

Shaik Shaheda Sultana*, Kameswara Rao S., Swati S. and Dr. T. Vani

ABSTRACT

The present work aimed at preparing fast dissolving buccal films of Curcumin solid dispersion, since Curcumin is a poorly soluble drug. The main aim of this is to provide quick onset of action, improved bioavailability and also to increase the patient convenience of administration. The rate of dissolution can be increased by incorporating the solid dispersed drug into film which are prepared by polyethylene glycol (PEG4000) and polyvinyl pyrrolidone (PVP k30) as polymers, Lycoat RS720 as a polymer and glycerine as a plasticizer using solvent casting method. The films were evaluated for their physiochemical parameters like disintegration time, surface pH, thickness, weight, percent moisture absorption, folding endurance, drug content and stability testing. It is concluded that as the ratio of drug to PEG 4000 or PVP k30 in solid dispersion increased the release rate increased, as the concentration of Lycoat RS720 increased the release rate decreased, as the concentration of glycerine increased the release rate increased and the solvent evaporation method gave greater drug release than fusion method. Formulation F6 showed 98.89% drug release from the film within 7 minutes which is an essential character for faster absorption.

Keywords: Fast dissolving buccal film, Curcumin, Solid dispersion, Lycoat RS720, solvent casting method.