Abstract

INFLUENCE OF CARBOPOL AND POLYOX ON THE RELEASE OF METOPROLOL SUCCINATE FROM EXTENDED-RELEASE MATRIX TABLETS: A DOE APPROACH AND IN-VIVO EVALUATION.

Sanjay Kumar Sahu* and Ashish Kumar Sharma

ABSTRACT

Metoprolol succinate is a selective beta-adrenergic receptor blocker useful in treatment of hypertension, angina and heart failure. The purpose of the present work was to design and evaluate controlled release matrix type tablet of Metoprolol succinate using Carbopol71G, PolyoxWSR301 and Eudragit L100-55 as a matrix forming agents. Effect of polymers combination was studied by design of experiments. Best Combination of Polymer was evaluated in pH 6.8 buffer using USP type II paddle at 50 rpm. PolyoxWSR301 was used to form firm gel with Carbopol71G polymer. Formulation with Optimum Concentration of Carbopol 71G, PolyoxWSR301 and Eudragit L100- 55 showed optimum drug release at 4 hours with clinical relevance. The Optimized formulation was compared with reference products (BelocZok 190mg) for dissolution study with proven bioequivalence.

Keywords: Metoprolol Succinate, Carbopol, Polyox, Eudragit, DoE.