Abstract

EVALUATION OF ANTHELMINTIC ACTIVITY OF ETHANOLIC EXTRACT OF GREWIA FLAVESCENS JUSS WHOLE PLANT.

G. N. Pramodini*, Dr. Shaik Mohammed Khasim, Dr. Parwez Alam, Syed Zaki Uddin, Neha Fathima, Minhaj Fatima, Shafeen Begum and Adiba Maheen

ABSTRACT

In Recent years there has been rapid increase in the infections caused by the helminthes and their development of resistance to most of the commercially available anthelimentics drugs. so, Plants clamied for possessing the anthelmintic property is getting attention these days. The traditionally clamied anthelimintics are sustainable and environmentally acceptable crude drugs. so, The present study is based on to evaluate the anthelimintic potential of ethanolic extract of Grewia flavescens juss whole plant by using Pheretima Posthuma as test worms (100mg/ml, 50mg/ml, 25mg/ml) of Grewia flavescens juss whole plant ethanolic extract were tested in the assay, which involved determination of time of paralysis (P) and time of death (D) of the worms it showed shortest time of paralysis (P=23 min) and death (D=42min) in 100mg/ml, while the time of paralysis and death will increase in 50mg/ml (P=26min) and D=48min) and in 25mg/ml concentration (P=32min) and (D=61min) respectively as compared to albendazole 10mg/ml used as standard reference (P=21min) and (D=44min) and normal saline as control. The results of present study indicated that the ethanolic extract Grewia flavescens juss (EEGF) whole plant showed potential therapeutic significant paralysis and also caused death of worms. so it is concluded that the plant Grewia flavescens juss proved for its traditional claim as an effective anhelimintic herbal drug.

Keywords: Grewia flavescens, anthelimentics, albendazole, Time of paralysis, Time of death.