HYPOGLYCEMIC AND ANALGESIC ACTIVITY OF ROOT EXTRACT OF RUMEX NEPALENSIS
Deepa Khatri, Sumit Bahadur Baruwal Chhetri, Prakash Poudel and Nirmala Jamarkattel*
ABSTRACT
Plants are an important source of novel pharmacologically active
compounds. Ease of availability, least side effects and low cost make
the herbal preparations the main key player of all available therapies,
especially in rural areas. The aim of present study was to investigate in
vitro α- amylase inhibition activity and in vivo hypoglycemic and
analgesic activity of ethanolic root extract of Rumex nepalensis. In vivo
hypoglycemic study was performed in normal and glucose loaded rats.
Analgesic activity was determined by using hot plate method. Result
revealed that R. nepalensis showed the dose dependent inhibition of α-
amylase enzyme with IC50 value 912.22 μg/ml. R. nepalensis (200
mg/kg) showed significant (p
Keywords: Rumex nepalensis, ?- amylase, hypoglycemic, analgesic.
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