Abstract

REVIEW OF INSULIN AND ITS ANALOGUE USE IN DIABETES MELLITUS AND ADVANCES IN INSULIN THERAPY

Athulraj*, Blessy David, Binu Francis and A. Vikneswari

ABSTRACT

Diabetes mellitus is defined as a heterogenous metabolic disorder characterized by common feature of chronic hypoglycemia with disturbance of carbohydrate, fat and protein metabolism.It is the most common of endocrine disorder..I t was estimated that more than 200 million people worldwide had DM and 300 million will subsequently have the disease by 2025. Diabetes mellitus may be classified according to aetiology by for the most common type being type -1 and type-2 diabetes. Type-1 diabetes(insulin dependent diabetes mellitus) is a disease characterized by destruction of the insulin producing pancreatic –β cells, it can caused due to autoimmune and idiopathic reasons(about 10% of the type-1 diabetes).Usually develops in the young (below the age of 30),although can develop in any age.Type-2(non insulin dependent type diabetes mellitus) is more common above the age of 40 with a peak of onset in developed countries between 60 and 70 years.

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