Abstract

REVIEW OF DETERMINATION OF NON ALCOHOLIC FATTY LIVER DISEASE WITH ITS COMORBIDITIES, PREVENTION AND MANAGEMENT

Binu Francis*, A. Vikneswari, Blessy David and Athul Raj

ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) is the accumulation of abnormal amounts of fat within the liver. Nonalcoholic fatty liver disease can be divided into isolated fatty liver in which there is only accumulation of fat, and non-alcoholic steatohepatitis (NASH) in which there is fat, inflammation, and damage to liver cells. NASH progresses to scarring and ultimately to cirrhosis, with all the complications of cirrhosis, for example, gastrointestinal bleeding, liver failure, and liver cancer. The development of nonalcoholic fatty liver disease is intimately associated with and is probably caused by obesity and diabetes. Nonalcoholic fatty liver disease is considered a manifestation of the metabolic syndrome. The symptoms of nonalcoholic fatty liver disease are primarily those of the complications of cirrhosis in patients with NASH; isolated fatty liver infrequently causes symptoms and usually is discovered incidentally. The complications of cirrhosis include gastrointestinal (GI) bleeding, mental changes (encephalopathy), accumulation of fluid (ascites, edema), Liver cancer.

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