Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF KETOPROFEN USING NATURAL GUMS

Supriya Nagori*, Dr. Rajesh Asija, Avinash Gupta, Ayush Garg

ABSTRACT

Sustained release tablets of Ketoprofen is a non steroidal antiinflammatory drug. Designing a sustained release formulation for the drug ketoprofen may prolong therapeutic concentration of drug in the blood and decrease the frequency of dosing and also improve the efficacy of drug and patient compliance. Ketoprofen sustained release matrix tablets were prepared by wet granulation method. The effect of gum damar concentration was studied by using three different drug polymer ratios. Gum damar was used as a hydrophilic release retarding polymer, and talc was used as a lubricant. The grannules were evaluated for pre-compression parameters like angle of repose, bulk density, tapped density and Carr’s index. This shows that the grannules had smooth flow properties ensuring homogenous filling of the die cavity during the compression (punching) of tablets. The tablets were evaluated for hardness, weight variation, friability, drug content uniformity, in vitro dissolution studies and model fitting analysis. The in vitro releases of ketoprofen from the prepared tablets were studied in pH 1.2 for 2 hr and phosphate buffer pH 6.8 for 6 hr. It was found that the formulation batch F2 showed good release profile as compared to other two formulations. F1 showed initial burst effect after two hours. The formulation batch F3 showed about 85% drug release it might be due to high ratio of drug to polymer or high swelling of gum damar which retard the drug release. From all the prepared formulations, the promising formulation was selected based on physicochemical properties and in vitro release studies.

Keywords: Ketoprofen, Gum Damar, Micro crystalline cellulose, Dibasic calcium phosphate, Sustained release matrix tablets.