Abstract

PREPARATION AND PHARMACODYNAMICS STUDY OF INSULIN IMPLANT TABLETS

Wang Qiongyan*, Zhou Guowei, Zhang Jianli, Zhao Na and Hu Liandong*

ABSTRACT

In this study, insulin implant tablets was prepared and its pharmacodynamics was studied in rats. Polylactic acid (PLA) and poloxamers were used as carriers to prepare insulin implanted tablets. In vivo pharmacodynamics of insulin-implanted tablets in rats was investigated. Glucose oxidase method was used to measure blood glucose concentration. The in vitro release of implants was influenced by the amount of Polylactic acid and poloxamer, the cumulative release of insulin was 81.9 ± 1.3% ~ 90.4 ± 1.5% after 36 hours. In vivo pharmacodynamics results showed that insulin implant tablets had a sustained release effect up to 84 h. The quality of insulin implants is easy to control, and the tablets can produce a sustained release effect. It can provide a convenient and effective way for diabetic patients.

Keywords: Diabetes; insulin; PLA; implant; pharmacodynamics.