Abstract

ANTIDIABETIC AND KIDNEY PROTECTIVE EFFECT OF ASPARAGUS RACEMOSUS IN ALLOXAN INDUCED DIABETES IN RATS

Wesam E.M., Yakout A.El-Senosi, Samy A. Aziza and Souad A. Ahmad.

ABSTRACT

The Asparagus racemosus was evaluated for its antidiabetic activities against alloxan induced hyperglycemia in rats. Thirty rats were used divided into 2 groups, normal control: Composed from 10 rats and diabetic group composed from 20 rats I.P.injection.of alloxan by dose 120mgm/kg b. w, This group subdivided into 2 subgroup: 1. Alloxan group: 10 rats as control negative. 2. Asparagus treated group: 10 rats administrated Asparagus racemosus powder by dose 500 mg/kg b. Wt. daily P.O. for 30days (Kumar et al., 2011 and Sara et al., 2013). Diabetes is recognized as a group of heterogeneous disorders with the common of hyperglycaemia and glucose intolerance, due to insulin deficiency, impaired of insulin action, or both (Harris and Zimmet, 1997). Diabetes mellitus (DM) is considered as impaired insulin secretion and (or) action. DM describes a group of metabolic diseases in which the person has high blood glucose level than normal, either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), increasingly thirsty (polydipsia) and hungry (polyphagia), (Teixeira et al., 2000). DM results in disturbances in carbohydrate metabolism (Barik et al., 2008) Daily administration of Asparagus racemosus to diabetic rats by dose (500 mg/kg b. wt.) for 30 days decreased serum glucose. These findings indicate that anti hyperglycemic activity of Asparagus racemosus mediated by inhibition of carbohydrate digestion and absorption, together with enhancement of insulin secretion and action in the peripheral tissue (Hannan, et al., 2011).

Keywords: Alloxan, Asparagus racemosus, kidney protection. Antidiabetes.