Abstract

A REVIEW:- INSTABILITY IN PAEDIATRIC DRY SYRUP OF ANTIBIOTICS

Vidhi A. Dadhaniya*, Dr. Nilesh K. Patel, Urvi J. Chotaliya, Ajay I. Patel, Grishma P. Nathwani and Swati H. Jolapara

ABSTRACT

Oral paediatric suspensions of antibiotics are mainly available as dry powders for reconstitution. Most of reconstituted antibiotic suspension is to be kept refrigerated in order to get the optimal therapeutic action from the drug. However many patients do not keep to it to specified storage conditions for many reasons. Like no refrigeration and irregular power supply that may result in various degree of degradation of reconstituted antibiotics. Pharmacists are therefore challenged how to counsel patients when there is no refrigeration or erratic power supply.[1] Inappropriate use of antibiotics leads to economically and clinically preventable negative consequences including unnecessary adverse effects, increase mortality and morbidity from treatment failure, wasting healthcare resources, and increase the emergency of bacterial resistance.[2] Improper storage condition leads to physical instability, chemical instability, reduction in potency, or it may also leads to serious adverse effect on the patient‟s health. Therefore storage conditions for reconstituted liquids must not be taken lightly. Present review will discuss instability problems associated with dry syrup of antibiotic and its feasible remedial measure, like proper storage condition, use of stabilizer, different packaging material.

Keywords: Antibiotic, stability, paediatric dry syrup, resistance.