![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
SYNTHESIS, CHARACTERIZATION AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL QUINOLINE DERIVATIVES
Gunda. Srilakshmi*, Dr. Srinivas R Adapa
ABSTRACT The Inflammation is a serious health problem in industrialized country due increase in pollution. In the present study a series of new quinoline derivatives (3a-l) were synthesized and evaluated for their anti-inflammatory activity by using the model of carrageenan induced mice paw edema in adult albino rat on comparison with standard Indomethacin. The maximum anti-inflammatory activity was recorded by the compound 3i and 3j having 71% protection of edema followed by compound 3c and 3d showed 69%, compound 3b and 3e having 64% protection of edema. The compound 3i and 3j showed more percentage protection of edema with compared with standard drug Indomethacin (75%). It has been found that the extent of increase in paw volume reduces significantly up to 5 hrs when compared with solvent control. Keywords: Anti-inflammatory activity, Carrageenan, Indomethacin, Quinoline. [Download Article] [Download Certifiate] |