Abstract

EVALUATION OF THE INTERACTION OF THREE TYPES OF ANTRACICLINES AND NEUROTRASMISORS USING QUANTIC CHEMICAL SIMULATION

Lillhian Arely Flores-González, Karina García-Aguilar, Iliana Herrera-Cantú, Erick Pedraza-Gress, Manuel Aparicio-Razo, Oscar Sánchez-Parada, Emmanuel Vázquez-López, Juan Jesús García-Mar and Manuel González-Pérez*

ABSTRACT

In this work we analyze three types of anthracyclines (ACys). The analysis consists of observing how these ACys interact with the neurotransmitters (NT). These drugs are used in the treatment of different types of cancer in human patients. The Hyperchem program was used to perform the simulation and calculations of quantum variables. As a result, we researchers observed that ACys have a high probability of interaction with NT. This interaction has different possible effects depending on the compound being analyzed. We conclude that the part of the central nervous system (CNS) that controls the mood of the patient is affected.

Keywords: Anthracyclines, neurotransmitters, Hyperchem, quantum analysis.