Abstract

SYNTHESIS AND IN-VITRO BIOLOGICAL EVALUATION OF SCHIFF’S BASE AND AZETIDINONE OF 6-ETHOXY 2-AMINO BENZOTHIAZOLE DERIVETIVES

Sathiya A.*, Dr. Sundara Pandian M., Dr. Palanivelu M., Packia Lakshmi M., Sathya Devi S. and Jothirani P.

ABSTRACT

A series of Schiff’s base of several derivatives have been synthesized and incorporated with azetidinone as biologically effective agent with good therapeutic values having minimum toxic levels. 6-ethoxy 2-amino benzothiazole was synthesized from 6-ethoxy aniline by refluxing with ammonium thiocyanate in acidic medium. 6-ethoxy 2- amino benzothiazole was then condensed with various aromatic aldehydes by using ethanol as solvent to yield different schiff’s bases. Azetidinones derivatives were synthesized from Schiff’s bases in the presences of chloroacetyl chloride, triethylamine and dioxane as solvent. The structures of synthesized compounds were characterized by IR, ¹H-NMR and Mass spectral analysis. Purity of the individual compound was confirmed by TLC. The synthesized compounds were evaluated for their in-vitro anti microbial activity against several staphylococcus aureus and klebsiella pneumoniae. All the compounds have shown significant anti-inflammatory and antibacterial activity which was compared with Diclofenac and Amikacin respectively as standard.

Keywords: 6-ethoxy 2-amino benzothiazole, Schiff’s bases, Azetidinones, Anti-inflammatory activity, Antibacterial activity.