Abstract

REVIEW ON APPROACHES OF IN-SITU OCULAR DRUG DELIVERY SYSTEM

Ayushi*, Jayshree Sundaria and Dr. Shiv Garg

ABSTRACT

The eye is the most complex and precious organ of the body due to its immediate pre-corneal elimination of dosage form. In order to overcome this, researchers developed a new system; in-situ gel forming system. This formulation undergoes a phase transition in the eye to form a gel, thus prolonging the precorneal contact time which will result in improved ocular bioavailability. The conventional ocular drug delivery systems like solutions, suspensions, and ointments show drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision respectively so there was a need for developing advanced drug delivery system. In situ forming polymeric formulations were developed to overcome the conventional drug therapy drawbacks these systems are in solution form before administering in the body, but once administered these systems undergo gelation. The formation of gels depends on factors like change in a specific physicochemical parameter (pH, temperature, ion-sensitive) by which the drug gets released in a sustained and controlled manner. These systems were evaluated for drug content, clarity, pH, gelling capacity, viscosity, in vitro drug release studies, texture analysis, sterility testing, isotonicity evaluation, accelerated studies and irritancy test. FT-IR spectroscopy was used to know drug and polymer incompatibilities.

Keywords: In situ forming polymeric, improved ocular bioavailability, gelling capacity, eye, polymer.