![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
ELECTROCHEMICAL STUDIES OF MODIFIED 2-HYDROXYPROPYL BETA CYCLODEXTRIN AND MODIFIED CARBON NANOTUBES SENSORS FOR DETERMINATION OF ANTI-DIABETIC PIOGLITAZONE HYDROCHLORIDE
Abdulkareem Abdulraheem, Maha F. El-Tohamy*, Hadi Abbas Alnajjar, Nabeel Alsaffar
ABSTRACT
The present study aimed to suggest a simple, accurate and sensitive electrochemical method for the potentiometric determination of pioglitazone hydrochloride (PLZ). The developed method was conducted by the incorporation of PLZ with sodium tetraphenyl borate (TPB) to fabricate four PLZ-TPB sensors using o-nitrophenyloctyl ether (o-NPOE) as a plasticizer in a polymeric matrix polyvinyl chloride (PVC). Sensor I and sensor II were conventional coated wire membrane type, while sensor II was modified using 2-hydroxypropyl beta cyclodextrin (β-CD) as ionophore. Sensor III and sensor IV were carbon paste type and sensor IV was modified using carbon nanotubes (CNTs). Under optimum condition the proposed sensors displayed Nernstian responses of 53.8±0.8 and 55.5±0.6, 57.1±0.4 and 57.7±0.1 Keywords: Pioglitazone hydrochloride; Carbon paste; carbon nanotubes sensor; 2-hydroxypropyl beta-cyclodextrin; Pharmaceutical dosage forms; Biological fluids. [Download Article] [Download Certifiate] |