Abstract

SYNTHESIS, CHARACTERIZATION, AND ANTI-BACTERIAL ASSESSMENT OF NEW GATIFLOXACIN ANALOGUES

Noor H. Nasser*, Meison Abdulbary, Sarah H. Shaalan and Esraa S. Hadi

ABSTRACT

New gatifloxacin analogues were synthesized by coupling with different sulfonamide derivatives (sulfanilamide, and sulfacetamide), using chloroacetyl chloride linker, in order to increase the bulkiness at position 7 of the flouroquinolone by that reduce the efflux of the antibiotic from the bacterial cells and bacterial resistance will reduced consequently. The chemical structures of the synthesized compounds were confirmed and characterized using FT-IR spectroscopy, and elemental microanalysis, in addition to some physicochemical properties as melting points and Rf values. The antibacterial study was showed comparable effect of the prepared compounds with Gatifloxacin. The largest inhibition zone was observed with compound IIa against bacteria Bacillus cereus and the lowest inhibition zone was observed with compound IIa against bacteria Proteus mirabilis.

Keywords: Gatifloxacin, Flouroquinolones, Bacterial resistance, Topoisomerase enzyme.