Abstract

ANTIFUNGAL ACTIVITIES OF SOME EXTRACTS OF STREPTOGYNA CRINITA ON IN VITRO GROWTH OF CANDIDA ALBICANS, CANDIDA TROPICALIS, CRYPTOCOCCUS NEOFORMANS AND ASPERGILLUS NIGER

Ackah Jacques Auguste Alfred Bognan, Yayé Yapi Guillaume*, Agré Don Josette, Diallo Abdoulaye, Atchio konan Julien and Djaman Allico Joseph

ABSTRACT

Mycoses establish one of the infectious pathologies furthermore in pus emergent especially because of its eukaryotic cellstructure.Thus he turns out to be necessary to solve this health problem by other medicinal alternatives especially that the current molecules present more and more limits. Thus the species Streptogyna crinita, a medicinal plant was selected to estimate its antifungal activity. Thus, by bioguided extractions, 3 extracts of which the aqueous extract (SAq), hydro-ethanol extract (S0) and the aqueous phase of a partition hexane-water extract (SH-E1) were tested in vitro growth of 4 fungal germs (Candida albicans, Candida tropicalis, Cryptococcus neoformans and Aspergillus niger). After incubation (48 hours) at 30 °C, it appears that the SH-E1 extract has the best values of antifungal parameters. The values of MFC are 580 μg/mL (Candida albicans and Candida tropicalis) and 1170 μg/mL (Cryptococcus neoformans and Aspergillus niger). The species Streptogyna critina is a medicinal plant with antifungal activity. SH-E1 extract is the most active extract.

Keywords: Antifungal activity, Streptogyna critina, phytotherapy.