Abstract

SILVER NANOPARTICLES FUNCTIONALIZED GEL: PHYSICO-CHEMICAL PROPERTIES AND ANTIBACTERIAL ACTIVITY AGAINST ESCHERICHIA COLI, PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS

Eduardo José Jucá Mallmann, Samuel Veloso Carneiro, Francisco Afrânio Cunha, Maria Conceição Dos Santos Oliveira Cunha, Everardo Albuquerque Menezes, Tamara Gonçalves-Araújo and Pierre Basílio Almeida Fechine*

ABSTRACT

This study was performed to verify the stability, physicochemical properties and antibacterial activity of a carbomer based gel functionalized with silver nanoparticles (AgNPs) obtained by green synthesis. Three formulations of Gel-AgNP were done: 0.5, 1.0 and 2.0% of AgNPs. The gel is skin-compatible and had shown interesting rheological properties, assuming a pseudoplastic profile. In addition, the stability of the gel was obtained and it was extremely satisfactory for six months. The antibacterial activity was performed against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus, showing satisfactory results for 1.0 and 2.0% AgNPs gels trough well-diffusion technique. The AgNPs gel could provide an alternative to conventional antibacterial formulations (topical use) for veterinary or human applications.

Keywords: Silver nanoparticles; Carbomer gel; Green synthesi