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STUDY OF ANTIOXIDANT, ANTIMICROBIAL AND ANTHELMINTIC PROPERTIES OF 1-NICOTINOYL-4-ARYL-3-METHYL 3a,4- DIHYDROPYRAZOLO [3,4c] PYRAZOLES AND THEIR INCLUSION COMPLEXES WITH ?-CYCLODEXTRIN
Sunakar Panda*, D. L. Singh
ABSTRACT Three different fused pyrazoles with nicotinyl moiety namely 1- Nicotinoyl-4- phenyl-3- methyl- 3a, 4-dihydropyrazolo [3, 4-c] pyrazole, 1-Nicotinoyl-4-(2-chlorobenzylidene)-3-methyl-3a, 4- Dihydropyrazolo [3,4-c] pyrazole and 1-Nicotinoyl-4- (4- chlorobenzylidene) -3-methyl-3a,4-dihydropyrazolo[3,4-c] pyrazole have been synthesized and characterized spectroscopically. To enhance the solubility and minimise the side effects of the above synthesized compounds, their inclusion complexes have been prepared with β-cyclodextrin. The stability of inclusion complexes has been ascertained from the study of spectral and thermodynamic properties. Finally, the compounds and their inclusion complexes have been screened for antioxidant, antimicrobial and anthelmintic properties. It is found that there happens a significant increase in antioxidant, antimicrobial and anthelmintic activities after the formation of inclusion complexes. Keywords: Fused pyrazoles, ?-cyclodextrin, Inclusion complexes, Thermodynamic properties, Pharmacological properties. [Download Article] [Download Certifiate] |