Abstract

SYNTHESIS, CHARACTERIZATION AND ANTI MICROBIAL SCREENING OF SOME SALICYL HYDRAZIDE SCHIFF BASES

P. V. Hemalatha*, T. Sudha, V. R. Ravikumar and V. Ganesan

ABSTRACT

Schiff bases also known as imines are important class of biologically active compounds showing wide variety of pharmacological activity. Salicyl hydrazide was synthesized from methyl salicylate by reaction with hydrazine hydrate. Salicyl hydrazide was then converted to Schiff bases by reacting with various aromatic aldehydes. Salicyl hydrazide reacted with cinnamaldehyde and formed a lime yellow coloured product, 2-hydroxy-N-[3- phenylprop-2-ene-1- ylidene] benzohydrazide (SHC). Similarly salicyl hydrazide reacted with furfural and formed an ash coloured product, N-[(furan-2-yl) methylidene]-2. hydroxy benzohydrazide, (SHF). The synthesized products were characterized by IR and NMR analysis. Salicyl hydrazide derived Schiff bases were evaluated for antimicrobial activity. Both the Schiff bases (SHC and SHF) did show antibacterial and antifungal activity. Salicyl hydrazide derived furfural schiff base (SHF) showed significant antibacterial activity against Klebsialla pneumoniae. Both SHC and SHF showed significant antifungal activity against Candida albicans and Aspergillus niger.

Keywords: Salicyl hydrazide, Schiff base, cinnamaldehyde, furfural, antibacterial, antifungal.