Abstract

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF LOSARTAN POTASSIUM SUSTAINED RELEASE MATRIX TABLET

Avinash V. Dhobale*, Arun M. Mahale, Mrunal K. Shirsart, Deepak A. Joshi, Gunesh N. Dhembre and Mahesh M. Thakare

ABSTRACT

The aim of this research work was to formulate and develop a fixed Dose Combination product in a two different strength using same blend for both the strengths of tablet as a SR tablet formulation. In the tablet, Extended Release layer consist of Antihypertensive Drug belonging to class β-selective adrenergic blocking agent without partial agonist or membrane stabilizing properties. Extended release preparation provides sustained release and reduces the chances of tough related side effects. In selected cases of extended release preparation of this drug used in treatment of hypertension and congestive heart failure. The clinical studies have shown beneficial role of this drug as an extended release preparation. The main objective of the present study was to develop, formulate and evaluate a matrix tablet by using hydrophilic natural retardant polymers which would retard drug release in upper GI tract and should start releasing the drug when it reaches the alkaline environment of small intestine. Metolose 90 sh and xanthan gum were investigated as the model hydrophilic retardant polymers. Wet granulation method was used for preparation of sustained release matrix tablets. Nine batches of tablets were prepared. The prepared tablets were subjected for pharmacopoeial and non-pharmacopoeial evaluation parameters including loose and tapped bulk density, compressibility index, hausner ratio, angle of repose, friability, hardness, thickness, weight variation, % drug content and in-vitro drug release studies. It can be concluded that the combination of hydrophilic polymers that are retardant in nature are better suited for sustained and controlled drug delivery system than the hydrophilic polymer alone.

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