Abstract

INTERACTION BETWEEN ANTI HYPERTENSIVE DRUGS AND OTHER CLASSES OF DRUGS IN CARDIAC PATIENTS

Fereshteh Jaferi* and Geetha K. M.

ABSTRACT

Drug interactions occur when the effect of one drug is changed due to co administration of another drug. It may results in the change of therapeutic response of the drugs. The objective of the study was to find the incidence and type of potential & clinically significant drugdrug interactions between antihypertensive drugs and other classes of drugs in the patients which were suffering from hypertension disease. A total of 200 hypertensive cases were included in this prospective, unicenteric, observational study at a tertiary care hospital in Bangalore. Out of 200 prescriptions with different classes of drugs, it was found that 116 and 41 drug-drug interactions were noted in the male and female groups respectively .these interactions were present with different antihypertensives which were co administered and also with other classes of drugs co administered with antihypertensive. The most frequent interaction was between Furosemide & Metoprolol 13(5.5%) in both males and females groups, the next higher interaction was between Aspirin & Telmisartan 9(3%). Out of 157 interactions, 138 were moderate interactions and 18 were major interactions.

Keywords: Cardiology; Hypertension; Drug interactions.