Abstract

DEVELOPMENT AND EVALUATION OF BIVALIRUDIN POLYMERIC NANO-MICELLES FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Shivaraj D. Sadekar*, Basavaraj K. Nanjwade, Arindam Basu Sarkar, Siddharth M. Patil, Priyanka K. Patil

ABSTRACT

In the present study the bivalirudin loaded polymeric micelles were prepared by micellisation technique using poloxamer 407 as polymer. The drug remained intact and stable in the TDDS during storage, with no significant chemical interaction between the drug and the excipients. Physicochemical parameters such as percentage yield, drug entrapment efficiency, particle size analysis studies were carried out. The prepared polymeric micelles exhibited satisfactory physical characteristics such as percentage yield, SEM, entrapment efficiency, IR studies, particle size distribution and polydispersity index. Among all the developed formulations, F1 containing 4gm of poloxamer 407 showed better release than other polymeric micelles formulations. In Order to know the release pattern of bivalirudin from different polymeric micelles formulations, in vitro diffusion studies were carried out using Keshry-Chein diffusion cell and pH 7.4 phosphate buffers as receptor medium. The absorption kinetics was subjected to regression analysis. The drug release pattern of F1, F2 and F3 followed zero order kinetics. On the basis of the in vitro characterization it was concluded that bivalirudin be administered transdermaly through polymeric micelles delivery system.

Keywords: Bivalirudin, micelles, polymeric nanomicelles, transdermal, drug delivery.