Abstract

A CASE SERIES ON ANTIBIOTICS INDUCED KIDNEY DISEASE

Lubna Sulthana*, Neena Baby, Haritha B. Nair, Neetha Sabu, S. Hemalatha, T. Sivakumar

ABSTRACT

The initial diagnosis of drug-induced kidney disease typically involves detection of elevated serum creatinine, blood urea and nitrogen for which there is a temporal relationship between the toxicity and use of a potentially nephrotoxic drug. Etiology of DIKD are idiosyncratic allergic drug interaction, long term exposure of a drug and hospitalization for longer period. Drug induced acute kidney injury has been implicated in 8% to 60% of all cases of in-hospital AKI and as such is a recognized source of significant morbidity and mortality. Therefore successful prevention requires knowledge of pathogenic mechanism of renal injury, patient related risk factors, drug related risk factors, and preventive measures, coupled with vigilance and early intervention. Here we discuss four cases of antibiotic induced kidney disease and their management. We had done the causality assessment by using WHO-UMC scale.

Keywords: Acute kidney injury, Drug Nephrotoxicity.