Abstract

DEVELOPMENT AND VLAIDATION OF SIMPLE UVSPECTROPHOTOMETRIC METHOD OF QUANTIZATION OF ORNIDAZOLE IN SOLID DOSAGE FORMULATION USING MIXED SOLVENCY CONCEPT.

Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi

ABSTRACT

Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Ornidazole by use of mixed solvency concept. Ornidazole shows maximum absorbance in the concentration range of 5-25μg/ml at 319 nm. Method of analyses have been validated for different parameters like linearity, accuracy, precision, LOD and LOQ. The percent drug estimated in tablet formulation of Batch-I and of Batch-II were 99.42±0.211 and 99.38±0.321 respectively. The range of percent recoveries varied from 99.09±0.380 to 99.70±0.151.phenol does not interfere above 300 nm. The analytical method was found to be simple, safe (free from toxicity), economic and eco-friendly.

Keywords: Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the pres