Abstract

SYNTHESIS & ANTIBACTERIAL ACTIVITY OF 2(2'-THIONE-4'(3'H)- QUINAZOLINONYL) 6'-FLUORO-7'-CHLORO-2'-IMINO (1,3) BENZOTHIAZOL DERIVATIVES

Ekta Pandey and Niladry Sekhar Ghosh*

ABSTRACT

In present work, flurochloro amiline was treated with KSCN in presence of bromine in glacial acetic acid and ammonia to get 2- amino-6-fluro-7-chloro (1,3)-benzothiazole, which was treated with hydrazine hydrate (99%) in the presence of concentrate HCl using ethylene glycol as solvent to get 2-hydrazino-6-fluro-7-chloro(1,3) benzothiazoles, which was condensed with antranilic acid presence of dry pyridine to get 2-amino N-(2'amino (1',3') benzothiazolyl 6'-fluoro- 7'-chloro) 4-(3H)-quinazoline. The above condensed product was treated with carbon disulphide in the presence of alcoholic potassium hydroxide to get 2(2'-thione-4'(3'H)-quinazolinonyl) 6'-fluoro-7'- chloro-2'-imino (1,3) benzothiazole. To this above product different aromatic aniline, PABA, piperzino, diphenylamine, N-Methyl piperzino, O-toludine in presence of DMF were treated to get newly synthesized compound through replacing at 7th position chlorine. The lead compounds of scheme I were characterized by melting point, TLC, calculated elemental analysis, UV, IR and 1HNMR spectral studies. Further they have screened for their antibacterial activity.

Keywords: Fluorine, Benzothiazole, Quinazoline. Antibacterial.