Abstract

FORMULATION AND STUDY OF CONTROLLED POROSITY OSMOTIC TABLET OF ACARBOSE

*Ganesh Sanker S. and Dr. Molly Mathew

ABSTRACT

In this study a controlled pore osmotic tablet of Acarbose was prepare and evaluated the various parameters. Acarbose is very high soluble anti-hypoglycemic drug which is an ideal candidate for zero order drug delivery release. The effect of osmogen, change in composition of coating solution and various physiochemical studies were conducted. The FT-IR studies revealed that no physiochemical interaction between excipients and drug. The in vitro study of Acarbose osmotic tablet shows a significant effect on dug release up to 12h. The drug release kinetic of optimized formulation follows zero order non fickian release mechanism. The observed data’s were found to be very close to predicted values of most satisfactory formulation which demonstrates the feasibility of the optimization procedure in successful development of porous osmotic tablet of Acarbose.

Keywords: Acarbose, CPOP, poly ethylene glycol, mannitol, sodium chloride, drug release kinetics.