Abstract

REVIEW ARTICLE ON “MICROSPONGE DELIVERY SYSTEM”

Neha Patil*, S. A. Tadvi and Dr. S. P. Pawar

ABSTRACT

In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is overcome by microsponge delivery system. Microsponges are tiny sponge like spherical and highly porous micro-sized particles with a unique ability for entrapping actives. They offers programmable release active drug into the skin in order to reduce systemic exposure and minimize local cutaneous reactions to active. These MDS‟s are closely related to microspheres, and used in the sun screens, creams, ointments, over- the-counter (OTC) skin care preparations, recently used in oral drug as well as biopharmaceuticals (peptides, proteins and DNA-based therapeutics) drug delivery. The present review introduces microsponge technology along with its synthesis, characterization, programmable parameters and release mechanism of MDS.

Keywords: Microsponge, Controlled release, Tissue engineering, oral delivery, Topical delivery etc.