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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

ANALYSIS OF THE EFFECT OF LEVODOPA ON NEUROTRANSMITTERS USING QUANTITY METHOD

Manuel Aparicio-Razo*, Oscar Sánchez-Parada, Javier Flores-Mendez, Jorge Tzompantzi-Texis, Nora Mercedes Sánchez-Parada and Manuel González-Pérez

ABSTRACT

The Benefit of the Levodopa or L-Dopa (LEV) to reduce the symptoms of Parkinson’s disease and have been studied and presented a concern for promoting the acceleration of neurodegeneration. The objective of the study is to determine, using the parametric semiempirical quantum method 3 (SE-PM3), that neurotransmitter (NT) has a higher affinity with LEV through Hyperchem professional software; it is possible to perform molecular models and analysis of the LEV and the nine primary NT. The result of the simulations of the quantum sediments reveals that Serotonin is the primary NT oxidized by the presence of LEV, correlating with multiple pathologies linked to the side effects of that drug.

Keywords: Levodopa, Neurotransmitters, Quantum Method, Hyperchem, SE-PM3.

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