Abstract

LIPID PEROXIDATION, ANTIOXIDANT PROFILE AND SOME BIOCHEMICAL PARAMETERS IN RAT APPLIED AMINOGLYCOZIDE

Enver Caner* and Yeter De?er

ABSTRACT

Amikacin were used for the treatment of infections caused by Gram (-) bacteria, have serious nephrotoxic and ototoxic side-effects. Effects of the amikacin administrated at therapeutic doses on blood lipid peroxidation, antioxidant profile and some biochemical parameters were observed in this study. A total of 40 female Wistar albino rats were used. Amikacin (15mg/kg/day i.p) was administered to the rats in the study group and physiological saline was administered to the rats in the control group for 14 days. Within these samples, the malondialdehyde (MDA), the glutathione (GSH), the vitamin A, E, C, ceruloplasmin, albumin, globulin, total protein, alkaline phosphatase (ALP), glucose, total bilirubin and blood urea nitrogen (BUN) levels were measured. The GSH, glucose, albumin and BUN levels in the study group were statistically significantly decreased compared to the first blood collection and to the control group (p˂0.05), and the total bilirubin level was increased. The changes in MDA, vitamin A, E, C, ceruloplasmin, ALP, creatine and globulin levels were not significant (p˃0.05). It was observed that amikacin did not affect lipid peroxidation formation within the blood; however it changed some antioxidant levels and biochemical parameters.

Keywords: Amikacin, Antioxidant, Lipid peroxidation, Biochemical parameters, Rat.