Abstract

ORAL GLUCOSE TOLERANCE TEST (OGTT) WITH METHANOL EXTRACT OF SENNA OBTUSIFOLIA WHOLE PLANT

Sabrina Irin, Md. Shamim Bappy, Md. Najmul Hossain and Mohammed Rahmatullah

ABSTRACT

Background. Senna obtusifolia is used in some traditional medicines as a blood glucose lowering agent in diabetic patients. The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Senna obtusifolia whole plants in glucosechallenged mice. Methods. Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Results. Administration of methanol extract of Senna obtusifolia whole plants (MESO) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice dose-dependently reduced blood glucose levels by 11.7, 20.1, 28.3, and 37.1%, respectively compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 36.7%. Conclusion. Methanolic extract of whole plants of Senna obtusifolia can effectively lower elevated blood glucose levels, which at the highest dose tested was as effective as glibenclamide.

Keywords: Antihyperglycemic, Senna obtusifolia, glibenclamide, OGTT.