Abstract

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF MEBEVERINE BY USING NATURAL POLYMERS

Nimmala Shanthi*, Jagtap Poonam, V.Geethanjali Goud, Adepu Ramesh,Y.Kiran Kumar

ABSTRACT

The aim of the present study was to formulate and evaluate sustained release matrix tablets of Mebeverine Hcl using various natural polymers to achieve high drug release control, reduce dosing frequency, increase bioavailability and increase patience compliance. These tablets were prepared by using direct compression method. The matrix tablets were characterized for pre-compression and post-compression studies. The formulation F6 showed satisfactory physical parameters and it was found to be stable among other formulations. The prepared tablets were found to be uniform with respect to thickness (5.7mm) and hardness (4.7kg/cm2). The friability (0.57%) and weight variation (500mg) of different batch of tablets were found within prescribed limits. Drug content (98.2%) was found uniform within the batches of different tablets. Optimized formulation (F6) as 99.98% for 12 hours. The kinetics of the dissolution process was determined by using various kinetic equations, e.g. Zero-order, First-order, Higuchi and Korsmeyer-Peppas equations. Based on kinetic models the formulation F6 fitted into Zero order, First order, Higuchi model and Korsmeyer-Peppas plot and show non fickian diffusion mechanism release.

Keywords: Mebeverine, Tamarind Gum, Sodium carboxy methyl cellulose, Direct compression, In vitro drug release studies.