Abstract

DEVELOPMENT AND INVITRO CHARACTERIZATION OF PROBENCID RAPIDLY DISINTEGRATING TABLETS BY USING DIFFERENT CO-PROCESSED SUPER DISINTEGRANTS

Amareshwar S.*, Swathi A., Prashanthi Y., Vishwanadham Y., Sreekanth D., Vivekananda B.

ABSTRACT

In the present work, an attempt has been made to develop fast disintegrating tablets of Probencid. Novel method of co processed super disintegrates technology was employed to formulate the tablets. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum drug release i.e., 98.16% in 30 min hence it is considered as optimized formulation. The F4 formulation contains CP2 as super disintegrate in the concentration of 50 mg. (CP 2 contains CCS and CP in 1:2 ratio).

Keywords: Probenecid, Co Processed Super Disintegrates, CCS and CP.