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ENHANCEMENT OF BIOAVAILABILITY OF ASENAPINE MALEATE BY INCORPORATING IN MELT-IN-MOUTH SUBLINGUAL FILMS
S. N. H. Pratap* and A. Krishna Kishore
ABSTRACT
Asenapine Maleate is an atypical antipsychotic drug used in the treatment of schizophrenia. The melt-in-mouth sublingual films (SLF’s) of Asenapine Maleate were prepared with an objective of immediate release; improve bioavailability of drug and patient compliance.In this study, Asenapine maleate is initially complexed with hydroxy propyl-β- cyclodextrin (HP-β-CD) using kneading method followed by molding into thin films. Poly ethylene glycol (PEG-400) and propylene glycol (PG) are used as plasticizers and ethanol-water mixture is used as solvent. Sublingual films were prepared by solvent casting method using various concentrations of hydrophilic polymers like sodium carboxy methyl cellulose (Na- Keywords: Asenapine Maleate, HP- ?-Cyclodextrin, Sublingual films, Bioavailability, in-vitro release studies. [Download Article] [Download Certifiate] |