Abstract

FORMULATION AND EVALUATION OF CURCUMIN PELLET COATED SYSTEM FOR COLON DELIVERY USING BIOPOLYMERS

Madhu Gudipati* and Ramarao Nadendla

ABSTRACT

In this present research work, the aim was to develop extended on targeted triple layer coated pellets filled capsule system of curcumin for chronotherapeutic treatment of colon cancer. So triple layer coated pellets of curcumin were prepared using pH sensitive polymers by using fluidized bed processor which was further filled into an empty gelatin capsule. The compatibility was assessed using FT-IR, DSC and SEM studies for pure drug, polymers and their physical mixtures. The prepared batches were subjected to physicochemical studies, drug content estimation, in-vitro drug release and stability studies. When FT-IR, DSC and SEM studies were performed, it was found that there was no interaction between curcumin and polymers used. The physicochemical properties of the entire prepared triple layer coated pellets batches were found to be in limits. The drug content percentage in the optimized formulation CUR11 was found to be 69.35±2.84. The optimized triple layer coated pellets-filled-capsule formulation CUR11 releases curcumin after a lag time of 1.95 ±1.35%, 10.92±2.04% and 69.35±2.84% at the end of 5, 12 and 24h respectively. Thus, a novel colon targeted delivery system of curcumin was successfully developed using biopolymers by filling triple layer coated pellets into an empty gelatin capsule shell for targeting colon cancer treatment.

Keywords: Curcumin, coated pellet system, colonic drug delivery, in-vitro study.