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FORMULATION AND IN-VITRO EVALUATION OF SEROTONIN-5HT-1b and SEROTONIN-5HT-1d RECEPTOR AGONIST AGENT-ZOLMITRIPTAN-AN ANTI-MIGRAINE DRUG
Dr. Shashidhar P.*, Dr. D. Ramakrishna, Dr. M. Sunitha and Syeda Humera
ABSTRACT Oral drug delivery systems occupy most common route of dosage form administration, of which oral disintegrating tablets plays key significant role in case of minimum time required to get effective therapeutic concentration of a given active pharmaceutical ingredient as ORDs tablets. The selected Zolmitriptan was prepared into oral disintegrating tablets using PRECROL, ACE SULFATE AND CROSSPOVIDONE as major inactive ingredients. FTIR spectra revels that, there is no significant interaction between the pure drug Zolmitriptan and other inactive ingredients used. Total 10 formulation trials were prepared of which trial T-10 was optimized based on the characteristic properties and in-vitro evaluation parameters. Physical evaluation of blends and tablets of all the trials gave optimum range results of angle of repose 23.3 to 28.8, weight variation 97-101, hardness 2.3 to 2.6Kg/Cm2 and friability was found to be 0.3 to 0.9 percent for all 10 trials. Melt granulation and direct compression techniques were implemented in present work to prepare ORDs tablets, among which trial T-10 tablets prepared by direction compression method were optimized. The % drug release was fitted to various kinetic models to see the release rate of drug form prepared in-house ORDs tablets, and release rate was observed to be KORESMEYER PEPPAS-0.989>FIRST ORDER-0.975>HIGUCHIS PLOT-0.926. The prepared ORDs tablets give immediate therapeutic activity in minimizing migraine. Keywords: ORDs, oral disintegrating tablets, Zolmitriptan. [Download Article] [Download Certifiate] |