Abstract

FORMULATION AND EVALUATION OF METRONIDAZOLE EMULGELS USING VARIOUS POLYMERS

Anees Fathima*, Amreen Fathima, T.umema Naaz, Shaheen Begum, Nameera Jabeen and R. Soundarya

ABSTRACT

The purpose of the present study was to develop and optimize the emulgel system for Metronidazole using different types of gelling agents: HPMCK4M, Carbopol 940 and Xantham Gum. The prepared emulgels were evaluated in terms of appearance, pH, spread ability, viscosity, drug content and in-vitro drug release. In-vitro release study demonstrated diffusion controlled release of metronidazole from formulation up to 12 hours. The drug release profile exhibited zero order kinetics. All the prepared emulgels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability, and with higher drug release than conventional gel as per USP. In case of all evaluation parameters carbopol based formulation showed better properties so, As a general conclusion, it was suggested that the Metronidazole emulgel formulation prepared with carbopol highest concentration was the formula of choice.

Keywords: Metronidazole, Carbopol 940, Xanthan Gum, optimization, Anti-Protozoal activity.