Abstract

SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE SAQUINAVIR BY USING SELF-EMULSIFYING DRUG DELIVERY SYSTEM

T. Hiranmai, G. Nagaraju* and V. Sirisha

ABSTRACT

A self-micro-emulsifying drug delivery system (SMEDDS) has been developed to enhance dissolution rate and oral bioavailability of saquinavir. The solubility of saquinavir was checked in different oils, surfactants and co-surfactants and ternary phase diagrams were constructed to evaluate the micro emulsion domain. The saquinavir SMEDDS was prepared using Capmul MCM (oil), Cremophor RL100 (surfactant) and labrafil (co-surfactant). The particle size was determined. Dissolution rate of saquinavir was measured by using 0.1 N HCL as diffusion media. Results of diffusion rate of saquinavir SMEDDS were compared with those of pure drug solution. Diffusion of saquinavir SMEDDS showed maximum drug release when compared to pure drug solution.

Keywords: Saquinqvir, Self-micro-emulsifying Drug Delivery System.