Abstract

AN EMERGING TREND ON BILAYER TABLETS

Prasanna Kumar Desu*, P. Likhitha, S. K. Muneer, R. Lakshmi Prasanna, P. Venkateswara Rao

ABSTRACT

Bi-layer tablets have been developed to achieve controlled delivery of different drugs with pre-defined release profiles. In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bilayer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. Several pharmaceutical companies are currently developing bi-layer tablets. For a variety of reasons: patent extension, therapeutic, marketing to name a few. To reduce capital investment, quite often existing but modified tablet presses are used to develop and produce such tablets.

Keywords: Bi-layered Tablets, Controlled delivery, Improved bioavailability, Uniform drug delivery.