Abstract

THE PROTECTIVE EFFECT OF FLAXSEED OIL SUPPLEMENTED WITH HIGH SOURCE OF BRANCHED CHAIN AMINO ACIDS AGAINST THE RATS TESTICULAR TOXICITY INDUCED BY LEAD ACETATE

Ahmed-Farid O. A.* and Mona A. Hassan

ABSTRACT

The study was performed to study the effect of whey protein against lead acetate induced toxicity in rats. The thirty two male albino rats were divided to four groups 8 rats for each. The 1st group served as a control. The 2nd injected with 20mg/kg b.w of lead acetate. The 3rd injected with lead acetate plus glutathione (50 mg/kg b.w). The 4th injected with lead acetate plus a mixture of flaxseed oil and whey protein (0.5ml/kg b.w plus 20 mg/kg b.w respectively). The experiment lasted for 60 days. Revealed data showed that the lead acetate increase testes reductive stress markers, decrease cell energy, decrease endogenous antioxidant enzymes and decrease serum testosterone level. On the other hand, another treatment ameliorates allnegative alteration. Obtained data concluded that treatments are a natural source of antioxidant that decreases oxidative stress markers and improves male reproductive performance.

Keywords: Flaxseed oil, whey protein, lead acetate, Glutathione, Reductive stress.