Abstract

SOLUBILITY ENHANCEMENT OF GLIPIZIDE BY USING SOLID DISPERSION TECHNIQUE

T. Hiranmai, G. Nagaraju* and G. Sirisha

ABSTRACT

Glipizide is a poorly water soluble drug (0.001μg/ml). In the present study, we are attempted to enhance the solubility using solid dispersion techniques. Solvent evaporation was used to prepare above formulations. Various drug- carrier ratios were used to verify the enhancement of drug release. Various higher grade PEG’s were used (PEG 8000, PEG 10000, PEG 15000, PEG 20000). The formulation with drug and PEG 20,000 showed superior drug release characteristics compared to other formulations. The formulations were evaluated for its dissolution profile, compatibility with excipients and changes in drug’s polymorphic nature. Stability studies indicated that there is no significant changes over the period of time.

Keywords: solid dispersions, higher grades of PEG’s, solvent evaporation method, and dissolution studies.