Abstract

ASSESSMENT OF CONTROLLED RELEASE FORMULATION FOR DIFFERENT DRUG IN SPANSULES

Sumedh N. Moharil*, Dr. Shivshankar D. Mhaske and Mahesh B. Narkhede

ABSTRACT

Spansules are a dosage form which was considered as one of the Advanced Drug Delivery System. Multidrug preparations can be delivered easily by spansules or granules in capsule technology. This type of delivery system designed to release a drug or a medicament at two or more different rates or in different span of time. A quick/slow release system provides an initial release of drug followed by a constant rate of drug release over a extended period or a defined period of time and in slow/quick release system provides release vice versa.[1] This will overall provide constant plasma drug concentration over a wide range of time. The drug release is followed by zero order kinetics so that constant release of drug is maintained. Biphasic release system is generally used when maximum relief is to achieved suddenly followed by sustained release phase over a prolong period of time to avoid repeated administration.[1]

Keywords: Spansules are prolong period of time to avoid repeated administration.