Abstract

ANTI CONVULSANT ACTIVITY OF OCIMUM TENUIFLORUM ON EXPERIMENTAL ANIMALS

E. Rajani*, Dr. P. Venkatesh, V. Durga Prasad, V. Bhavani, S. Likhitha, M. Naresh, G. Sarojanamma

ABSTRACT

Epilepsy is defined as the repeated occurrence of sudden, excessive and/orsynchronous discharges in cerebral cortical neurons resulting in disruption of consciousness, disturbance of sensation, movements, impairment of mentalfunction, or some combination of these signs. The purpose of this investigation was to explore anticonvulsant activity of the leaf extract of Ocimum tenuiflorum using maximum electrical shock induced convulsion in rats. Ocimum tenuiflorum is an indegenious plant belonging to family Laminaceae, commonly known as krishna tulsi. Freshly powdered leaves were extracted with 70% ethanol. The convulsion is induced by electric shock to rats and those showing response were divided into four groups of six animals each. The group I treated with normal saline 1%, group II treated with Sodium valproate (90mg/kg), group III were treated with ethanolic extract of OTLE (100mg/kg) and group IV were treated with ethanolic extract of OTLE (200mg/kg). The ethanolic extract shows significant anticonvulsant activity by lowering the duration of extension phase (3.73 ± 0.59) when compared to control group (8.97 ± 0.47). From this research we concluded Ocimum tenuiflorum had significant anticonvulsant activity.

Keywords: Ocimum tenuiflorum, Sodium valproate, OTLE, Convulsion, Intra peritoneal,