Abstract

PREVENTION OF DIABETE COMPLICATIONS BY HYDRO-ETHANOLIC EXTRACT OF THE LEAVES OF TRILEPISIUM MADAGASCARIENSE LEEUWENBERG D.C. (MORACEAE)

Raoul AMPA*, Cyr Jonas MORABANDZA*, Gabriel AHOMBO, Etienne NGUIMBI, Martin DIATEWA, Ange Atoine ABENA, Théophile DIMO, Jean Maurille OUAMBA

ABSTRACT

This study was initiated to contribute to the prevention of diabetes complications. The rats are made diabetic by injection of streptozotocin (60 mg/kg) then oraly treated with hydro-ethanolic extract of T. madagascariense (400 mg/kg) leaves during 3 weeks. It come out that, hydro-ethanolic extract of T. madagascariense leaves at the used dose brings back glycemia towards the normal from the second week ; restores hepatic and renal functions by a significant descrease of creatinin (p<0.05) and plasmatic transaminases rates (p<0.01) compared to the untreated diabetic rats. The extract significantly standardizes (p<0.01) lipidic parameters, atherogenicity index and avoids the weight loss. These preliminary results suggest that the leaves of T. madagascariense are endowed of antidiabeticpotentiality and, open a prospect towards the development of a traditional drug improved against diabetes and its complications.

Keywords: T. madagascariense, leaves, hydro-ethanolic extract, diabetes.