Abstract

ENHANCEMENT SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY NANOBIOCOMPOSITES USING MICROWAVE INDUCED DIFFUSION (MIND) METHOD

Surendra G. Gattani and Shailesh L. Patwekar*

ABSTRACT

Solubility is one of the important factors to achieve required concentration of drug in systemic circulation for pharmacological action. At present only 8% of new drug candidates have both high solubility and permeability. More than 1/3 of the drugs listed in the U.S. Pharmacopoeia fall into the poorly water-soluble or waterinsoluble categories. Hence there is need of enhancement of solubility and dissolution of such type of drug. In this study, we increase the solubility and dissolution of practically insoluble drug Ibuprofen by converting into Nanobiocomposite using microwave-induced diffusion (MIND), which ultimately leads to enhanced bioavailability. In this study, we use biodegradable polymer rather than non-biodegradable polymer. The addition of biodegradable polymer into nanofiller production of novel class of materials called Nanobiocomposite. We have used the Microwave induced synthesis method which is a promising and novel synthesis method for the polymer nanobiocomposite. Nanobiocomposite formed by using natural polymer such as Acacia and Ghatti Gum with the help of microwave-induced diffusion (MIND). On the basis of their wetting and surfactant properties polymers were selected. Solubility study and dissolution study was carried out to check the enhanced properties of Nanobiocomposite. Formulated Nanobiocomposite were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), X-ray Diffraction Study (XRD), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM), Particle size distribution. Finally it was found that, the concentration of polymer into the composite enhances the solubility and dissolution of Ibuprofen. The optimized ratio of drug to polymer for all composite was found to be 1:2. In this work we use novel method for the preparation of nanobiocomposite by microwave irradiation. It was found to be fast, convenient, mild, energy-efficient, higher yields, high purity products, short residence time and environment friendly to produce nanobiocomposite in one step. Hence, this study demonstrates the use of microwave assisted Nanobiocomposite to enhance solubility and dissolution of drug.

Keywords: Nanobiocomposite, Ibuprofen, Microwave–induced synthesis method, Natural polymer.